| 刘兆麟.静电纺串珠纤维形貌结构及载药性能的研究进展[J].材料导报,2017,31(3):21-25 |
| 静电纺串珠纤维形貌结构及载药性能的研究进展 |
| Morphology and Drug Encapsulation Properties of Electrospun Bead-on-string Nanofibers:A Review |
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| DOI：10.11896/j.issn.1005-023X.2017.03.004 |
| 中文关键词: 静电纺串珠纤维 形态特征 成形机制 形貌调控 载药性能 |
| 英文关键词: electrospun bead-on-string nanofibers, morphological characteristics, forming mechanisms, morphology controlling, drug encapsulation |
| 基金项目:河北省高等学校科学技术研究项目(QN2016225)；河北科技大学五大平台开放基金课题(2015PT60) |
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| 中文摘要: |
| 药物突释现象是阻碍静电纺载药纳米纤维发展的瓶颈,静电纺串珠结构纳米纤维可以通过珠粒有效担载药物,为解决药物的存储和控释问题提供了新思路。然而,串珠纤维的结构影响因素复杂,制备过程不稳定,因此,对串珠纤维形貌结构的调控及药物担载性能的研究越来越受到关注。对比了静电纺串珠纤维的各种不同形态,指出能够实现载药功能的串珠纤维应具备的形态特征,探讨了静电纺串珠纤维的成形机制,系统地分析了溶液性质和纺丝工艺参数对串珠纤维形貌结构的影响,并介绍了串珠纤维对药物的存储、释放性能。 |
| 英文摘要: |
| Drug burst release phenomenon hinders the development of electrospun drug-loading nanofibers. Electrospun bead-on-string nanofibers can carry drug particles effectively by the beads, which provide a new solution to drug encapsulation. However, the influencing factors of morphology and preparation process of the bead-on-string nanofibers are very complicated and unstable. Therefore, morphology controlling and drug encapsulation properties of the bead-on-string nanofibers become the research hot spot recently. Different structures of the beaded nanofibers are compared and the morphology which can realize drug encapsulation is clarified. The forming mechanisms of the bead-on-string nanofibers are discussed. The influence of solution properties and processing parameters on morphology of the beaded nanofibers is analyzed. Finally, drug encapsulation performance of the bead-on-string nanofibers is introduced. |
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